Structures of several clinically relevant NUDT15 variants are discovered – paving the way for better cancer treatments

Recent research by a group of researchers from Sweden, the US, and the UK successfully developed a specific NUDT15 inhibitor, TH7755, that helped the group to obtain structures of clinically relevant NUDT15 variants: Arg139Cys, Arg139His, Val18Ile, and V18_V19insGlyVal. These insights allow further understandings of the structural basis of thiopurine intolerance in patients carrying these NUDT15

MAX IV & partners poised to innovate life science sector

MAX IV Laboratory, together with Science for Life Laboratory (SciLifeLab) and the European Spallation Source ERIC (ESS), form the joint Science Hub InfraLife, Infra Access for Life Science Sweden. Recently launched, InfraLife supports Sweden’s national investments in large-scale research infrastructure through dynamic facilitation and access to cutting-edge technology, data science, and active industry-enabling collaboration, outreach, and