In a study combining structural biology, biochemical and genetic approaches, scientists showed that plant cell-surface receptors employ a mechanism for error correction responsible for the control of receptor activation and signaling select bacterial symbionts. This demonstration opens the door to potentially manipulating such receptors’ binding sites in legumes and other organisms in the future.
Understanding NUDT15: lessen the efficacy of HCMV treatment
Ganciclovir, a regular medicine used to treat human cytomegalovirus (HCMV) infections, was found less efficient when reacting to human’s NUDT15 enzyme — based on a recent BioMAX study. This finding gives further insight into pharmaceutical treatments’ efficacy in HCMV cases. Although being regarded as a common disease, HCMV infections might cause severe consequences for immunocompromised
Aarhus scientists investigate secrets behind mantis shrimp clubs at DanMAX
Mantis shrimp or stomatopods, intrigue humans due to their beauty but also fierce predatory behavior.
HALOS – A unique collaboration in Life Science
A new EU project in the program area Öresund-Kattegatt-Skagerak (ÖKS) has been approved. The Hanseatic League of Science (HALOS) will build a unique collaboration between Hamburg and South-West Scandinavia, bring together the four unique research facilities MAX IV, ESS, DESY and European XFEL, and create a centre for integrated, world-leading Life Science innovation and research.
Structures of several clinically relevant NUDT15 variants are discovered – paving the way for better cancer treatments
Recent research by a group of researchers from Sweden, the US, and the UK successfully developed a specific NUDT15 inhibitor, TH7755, that helped the group to obtain structures of clinically relevant NUDT15 variants: Arg139Cys, Arg139His, Val18Ile, and V18_V19insGlyVal. These insights allow further understandings of the structural basis of thiopurine intolerance in patients carrying these NUDT15
MAX IV & partners poised to innovate life science sector
MAX IV Laboratory, together with Science for Life Laboratory (SciLifeLab) and the European Spallation Source ERIC (ESS), form the joint Science Hub InfraLife, Infra Access for Life Science Sweden. Recently launched, InfraLife supports Sweden’s national investments in large-scale research infrastructure through dynamic facilitation and access to cutting-edge technology, data science, and active industry-enabling collaboration, outreach, and