We make the invisible visible
Diffraction pattern recorded during ptychographic scans using the Siemens star test sample. The large overall size of the signal on the detector indicates that even the smallest features of the sample contribute to the signal and can thus be reconstructed. Interference fringes (the separation between the intensity maxima and intensity minima) can clearly be seen,
The crystal structure of MtMce4A39–140 shows four molecules in asymmetric units. The structure of the substrate-binding mammalian cell entry (Mce)4A protein from Mycobacterium tuberculosis, the causative agent of the disease Tuberculosis, was unknown — until recent research at BioMAX beamline. It showed the unique Mce domain of Mce4A, a part of the cholesterol importing complex of
Measuring the coincidence time resolution of the detectors in a TOF-PET test setup at CERN laboratory in Switzerland. Credit: Stefan Gundacker An international collaboration led by CERN, European Organization for Nuclear Research, studied the efficiency of next-generation silicon photomultipliers (SiPMs) using barium fluoride crystals when excited with X-ray and gamma photons. Their findings on scintillation
Inhibition of the interaction between Keap1 and Nrf2 proteins can help to prevent and reduce oxidative stress which, when left untreated, can cause neurological diseases, cancer, as well as cell and tissue damage. In a new project, scientists broke down existing compounds that have shown the ability to inhibit the Keap1–Nrf2 protein-protein interaction into fragments
Researchers used an electron beam derived from MAX IV’s electron gun at the MAXPEEM beamline to break borazine molecules into fragments thus enabling the synthesis of amorphous boron nitride onto an otherwise inert graphene film. The results of the experiment indicate that electron beam-induced deposition of borazine actually impacts its boron nitrogen bonds. This effect
Fungal enzymes play an important role in the breakdown of plant cell walls during plant degradation. An international collaboration of researchers explored the auxiliary activities 7 (AA7) enzyme family, characterizing four fungal enzymes and uncovering a novel class of flavo-enzymes, exemplified by oligosaccharide dehydrogenase. The enzymes fuel the activity of lytic polysaccharide monooxygenases (LPMOs) in
An advanced data analysis platform for the crystallographic fragment screening (CFS) method is available for users and other partners of MAX IV. This web-based data analysis platform facilitates data processing, structure refinement, automated ligand fitting, multi dataset analysis, and even data visualization of CFS method experiments at the BioMAX beamline — bringing CFS project management
Researchers from the Swedish University of Agricultural Sciences (SLU), Alnarp, found that extrusion processing of quinoa grains increased its protein crosslinking and specific fiber type solubility. At the same time, the nanostructure investigated by SAXS and WAXS showed that extrusion processing caused morphological changes in the protein and starch of the extruded quinoa foods. While
NUDT15 bound to TH7755. Credit: Emma Scaletti Recent research by a group of researchers from Sweden, the US, and the UK successfully developed a specific NUDT15 inhibitor, TH7755, that helped the group to obtain structures of clinically relevant NUDT15 variants: Arg139Cys, Arg139His, Val18Ile, and V18_V19insGlyVal. These insights allow further understandings of the structural basis of
Inside MAX IV’s Energy Central building in Lund. Credit: Kraftringen AB Sustainability measures, when applied intelligently, bolster societal productivity and deliver tangible improvements to the natural environment. Some argue that world economies cannot survive the impacts of business as usual in terms of pollution and high energy demands. In Lund, sustainability in work and life