We make the invisible visible
Researchers from Uppsala University have identified a molecule that can be developed into a drug to treat COVID-19. The molecule was discovered by using structure-based virtual screening and has a strong ability to inhibit both SARS-CoV-2 replication and the previously known variants of the coronavirus. This research was a part of the SciLifeLab and KAW
Image: The chip developed by researchers during the project. Credit: Saketh Ram Mamidala Researchers from Lund University benefitted from MAX IV laboratory to find solutions to the long-standing technological challenge: the von-Neumann bottleneck. After nearly year-long research during the pandemic, they successfully integrated the processor and memory onto a single vertical nanowire in a 3D
Image: En route during the sampling expedition to the Qaidam Basin, in Qinghai Province, China. Credit: Xiangrui Kong How does one learn more about the characteristics of the Martian atmospheric chemistry and climate system while seated 56 million plus kilometres away? Using MAX IV’s HIPPIE beamline, an international research group studied the surface solvation of
image: (left) 3D volume rendering (iso-surface) of crystalline Si-star with Bragg-ptychography, (center), atomic displacement along the z direction. The color map shows strain (dimensionless) (right) SEM image of the same Si-star sample, for comparison. Credit: Dina Carbone To capture extraordinary nanoscale details in crystallography takes the powerful coherent flux of a 4th generation light source.
Illustration of the surface layers of the nickel superalloy and X-ray data. Credit: Alfred Larsson To develop longer-lasting metallic materials for harsh operating conditions requires understanding of their surface composition, structure and properties. A Swedish research group investigated the surface chemistry and thickness of the protective native oxide layer of nickel superalloys at MAX IV’s
Ganciclovir, a regular medicine used to treat human cytomegalovirus (HCMV) infections, was found less efficient when reacting to human’s NUDT15 enzyme — based on a recent BioMAX study. This finding gives further insight into pharmaceutical treatments’ efficacy in HCMV cases. Although being regarded as a common disease, HCMV infections might cause severe consequences for immunocompromised
Illustration of the virus SARS-CoV-2, the causative agent of Covid-19. Credit: Pixabay An international collaboration of scientists identified four fragments that interact with the nsp10 protein of the SARS-CoV-2 virus using the FragMAX platform and BioMAX beamline. The fragments could be used to develop inhibitors that supplant key enzymes activated by the protein—an application which
Experimental setup for tele-ptychography at NanoMAX beamline. Credit: Angel Rodriguez-Fernandez Researchers at MAX IV measured echoes produced by silicon crystals using the coherent X-ray based technique, tele-ptychography, at NanoMAX imaging beamline. Their findings reveal that strain can be used to tune the time delay of echoes, an important step for tailoring ultrafast X-ray optics. “The
Diffraction pattern recorded during ptychographic scans using the Siemens star test sample. The large overall size of the signal on the detector indicates that even the smallest features of the sample contribute to the signal and can thus be reconstructed. Interference fringes (the separation between the intensity maxima and intensity minima) can clearly be seen,
The crystal structure of MtMce4A39–140 shows four molecules in asymmetric units. The structure of the substrate-binding mammalian cell entry (Mce)4A protein from Mycobacterium tuberculosis, the causative agent of the disease Tuberculosis, was unknown — until recent research at BioMAX beamline. It showed the unique Mce domain of Mce4A, a part of the cholesterol importing complex of