31 March 2023, 13:45 - 14:30
Scientifika Webb

We warmly invite you to participate to our series of scientific seminars organised by the User Office at MAX IV.

Where (Zoom) call-in
When – Mondays 13:45 CET
Format – 30 minutes of presentation followed by 15 minutes of discussion, chaired by MAX IV staff

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Next talk in the PROGRAMME:

Speaker: Leandro R.S. Barbosa – Brazilian Synchrotron Light Laboratory
Session Chair: Fátima Herranz
Associated beamline: CoSAXS

Abstract: In this seminar, the speaker will talk about two main topics. Firstly, about SAPUCAIA (Scattering APparatUs for Complex Applications and In-situ Assays) beamline, the new SAXS beamline at Sirius, Brazil. This facility will be dedicated to the study of small-angle scattering for both in-solution and solid samples. The beamline was designed to cover a large q-range and large X-ray energy range (from 6 to 17 keV).  Moreover, Sapucaia was also designed to have a small parasitic background for in-solution experiments. To do so, the beamline has no windows (windowless beamline). Thus, the entire beamline is supposed to be at low pressure (from 10-8 at the kyma undulator source to 10-3 mbar at the detector). Besides that, the beamline was installed in a high-b section of the storage ring, to have the smallest possible divergence. The beamline has a 15m-long tunnel, to have the detector (Pimega 540D) and also to cover a large q-range. Sapucaia is a versatile beamline, being able to perform several different SAXS experiments, like conventional SAXS; Time-resolved SAXS (TR-SAXS); Anomalous SAXS (aSAXS), which are particularly interesting for soft matter research. In the second part of my talk, we will address my research regarding the study of lipidic nanoparticles. Cubosomes are nanoparticles constructed with a particular mixture of certain amphiphilic compounds, like phytantriol (PHY), and a nonionic polymer, like poloxamer (F127). Cubosomes make excellent options for drug delivery systems since they have a high hydrophobic volume (> 70%, depending on the inner cubic structure). And the investigating of these nanoparticles, focusing on how external molecules affect the size, shape, and internal structure of the nanoparticles. The speaker will show the influence of external molecules on the inner structure of cubosomes using both SAXS as well as Cryo-EM methodologies.

*Read more about this seminar.