image: (left) 3D volume rendering (iso-surface) of crystalline Si-star with Bragg-ptychography, (center), atomic displacement along the z direction. The color map shows strain (dimensionless) (right) SEM image of the same Si-star sample, for comparison. Credit: Dina Carbone To capture extraordinary nanoscale details in crystallography takes the powerful coherent flux of a 4th generation light source.
In the sphere of human antibody therapeutics, the DutaFab platform shows broadening potential. Pharmaceutical giant Roche has developed ‘dual targeting’ Fab molecules containing two spatially independent binding sites for targeting distinct antigens. Their recent study, published in Nature Communications, demonstrates the high efficacy of these bispecific monoclonal antibodies for VEGFA and PDGF-BB growth factors related