The Foundation for Strategic Research, SSF, awarded over SEK 236 million to 33 different projects to promote the development of instruments, methods and technologies that provide the prerequisites for future, advanced research and innovation. One of the researchers who was granted funding is Kajsa Sigfridsson Clauss who is a scientist at the Balder beamline at MAX IV.
Here is an interview with her about the project.
What is the money granted for?
– Swedish Foundation for Strategic Research (SSF), call ITM-17, granted funding for the project “AdaptoCell for MAX IV laboratory users”. The goal of this project is to develop a microfluidic flow-cell platform, the AdaptoCell, for MAX IV users. Since biology is temperature and time dependent it will be especially useful for our life science users to study proteins at physiologically relevant conditions. Deployed at three different beamlines with three different techniques, Balder, CoSAXS and MicroMAX, the AdaptoCell can be used to investigate many things, for example looking at time dependent changes in the active site of enzymes, protein dynamics in response to stimuli or sample delivery for serial crystallography. The ready devices will be equipped with additional optical probes to allow simultaneous optical spectroscopy and X-ray data collection. This would allow the researches to relate well know sample signatures known from the home lab to the new data. Importantly, the microfluidic flow cell will deliver fresh sample in the X-ray beam and thereby keep down the sample volume needed. The three years-grant from SSF includes (money) funding for two postdocs to work together with the project team and experts on the development and release of three versions of the Adaptocell for MAX IV users. The project is a team effort with competences from the three X-ray techniques at MAX IV, the microfluidics device manufacturing at Uppsala University, and from protein production and experienced users at Swedish academia and industry.
Why is it interesting for you?
– This sample delivery system opens up for advanced X-ray absorption and emission spectroscopy studies of metalloproteins to better understand biocatalysis, which is science close to my heart. I also want to provide all our users at the Balder beamline, not only the protein scientist, access to a versatile liquid flow cell platform.
What do you hope the outcome of the project will be?
– The users of MAX IV will have a convenient and adaptable sample set up to investigate liquid samples with multiple techniques, which will enable new science at our beamlines. The new science discoveries will make a difference to the public in generation of novel solutions for the pharmaceutical and medical research industry in the study of biopharmaceutics, protein dynamics and biocatalysis, as well as create advances in materials research with catalysis and industrial production/processing.
How does it feel to have been granted the money?
– I am very excited to have received the resources needed to drive this project forward, to make the AdaptoCell a go-to sample platform for many of our users together with my colleagues and collaborators.