First published results from BioMAX

First published results from BioMAX



The first day of user data collections at the BioMAX beamline at MAX IV has now resulted in the first scientific publication and the first three-dimensional structure of a protein deposited in the international protein data bank. The first publication presents a new method for solving protein structures of challenging samples but the method can also be used for labelling proteins to make it possible to follow them in cells using imaging methods.

BioMAX was one of the first beamlines at MAX IV to come in operation. The first samples from external users were studied on December 16th 2016. In April – June 2017 BioMAX had a first period of limited access user operation. After a shutdown for upgrades, MAX IV is now starting up again and BioMAX will have regular users from December 2017.

The time from data collection until publication of the scientific results are typically between a few months and a few years. Not all data collection results in a scientific publication as it is often part of long and challenging work to produce the samples and succeed in determining a structure, and then to fit this piece into the puzzle that answers a scientific question. It is therefore very encouraging that the first day of user operation resulted in the first publication from BioMAX.


Press release from Aarhus University:
http://mbg.au.dk/en/news-and-events/news-item/artikel/llama-derived-nanobodies-as-a-new-tool-in-solving-crystal-structure/


Scientific publication:
Simon Boje Hansen, Nick Stub Laursen, Gregers Rom Andersen and Kasper R. Andersen “Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures” Acta Cryst. D73, 804-813 (2017).


Protein Data Bank entry:
http://www.rcsb.org/pdb/explore/explore.do?structureId=5nlw