Scientists detect key structures responsible for coupling process in sugar symporters and decode active sugar transport in plants

Researchers from Aarhus University achieved breakthrough insights about the coupling process that allows active sugar transport in plants aided by MAX IV’s BioMAX beamline. They successfully detected the inward and outward confirmations of the symporter Sugar Transport Protein 10 (STP10) – a protein responsible for monosaccharide transport across cell membranes – at high resolutions (1.8

Structures of several clinically relevant NUDT15 variants are discovered – paving the way for better cancer treatments

NUDT15 bound to TH7755. Credit: Emma Scaletti Recent research by a group of researchers from Sweden, the US, and the UK successfully developed a specific NUDT15 inhibitor, TH7755, that helped the group to obtain structures of clinically relevant NUDT15 variants: Arg139Cys, Arg139His, Val18Ile, and V18_V19insGlyVal. These insights allow further understandings of the structural basis of