Beamline project (currently not funded)

 

Imaging organs and tissues in vivo at the micrometer scale

Functional anatomy of insects, fish and other organisms

Visualisation of processes in food science, polymer foams

The scientific focus of the biomedical imaging beamline MedMAX is to visualize complex structures and processes in life sciences and soft matter down to the sub-micrometer spatial resolution. The method proposed to achieve this goal is hard X-ray tomographic microscopy.

For a number of conditions that affect humans health the detailed conceptual understanding of the underlying biological processes is still missing. The clinical imaging systems cannot access the spatial resolution domain that is critical to forming a complete picture of a functioning organ, tissue.

Pre-clinical studies at the MedMAX beamline will contribute to building profound knowledge on the origins of various poorly understood biological processes by enabling micrometer resolution functional anatomy and pathoanatomy of small animals and tissues.  Among others, the imaging instrument will welcome scientists active in developmental biology, pre-clinical research, plant science, soft matter, food science, paleontology, zoology, environmental science, cell biology.

The main technical design goal of the MedMAX beamline is to pioneer high spatiotemporal resolution in vivo and in situ imaging and push the frontiers of time-resolved micrometer resolution imaging of biological and soft matter.

The MedMAX beamline project is in the definition phase and when built will be part of the MAX IV imaging group.

The beamline will serve the user community in three modes of operation:

  • micrometer resolution in vivo and ex vivo tomography
  • medium (10-30μm) resolution fast in vivo tomography
  • nano holo-tomography (with basic spectroscopic capabilities)

 

All three instruments will be optimized to produce virtual volumes representing the electron density of the sample. The main contrast mechanism will originate from the X-ray phase shift when the highly coherent X-ray beam interacts with distinct electron density regions of the sample.

 

Contact

Project leader Rajmund Mokso

Spokesperson Martin Bech

 

Technical details

X-ray source (IVU): undulator

Energy (wavelength) range: 12–35 keV (1–0.3 Å)

X-ray energy bandwidth: ΔE/E ~ 0.1–1 %

Beam modes: parallel beam, focused beam, expanded beam

Focusing optics: Kirkpatrick-Baez mirror pair

Beam size at sample: Natural beam  ~ 2×2 mm (with beam expander: 30×30 mm)

Flux at sample at 0.5 Å: 1014 photons/s

Experiment set-up: Microtomographic endstation, in vivo small rodent imager, nano-holotomography

Spatial resolution: 0.1- 30 μm