Research in a wide range of disciplines – materials science, nano-science, heterogeneous catalysis, corrosion science, polymer science to name but a few – is in strong need of improved surface imaging techniques with structural, chemical, electronic, and magnetic contrasts at spatial resolutions in the nanometer range. Spectroscopic PhotoElectron and Low Energy Electron Microscope (SPELEEM) is unique in that it provides easy access to all of these contrast mechanisms at resolutions in the nanometer range in a single instrument. One of recent and the most important developments concerning this instrument is the upgrade to a microscope with an aberration corrector, which improves the spatial resolution of the microscope by an order of magnitude while increasing the transmission by a similar factor. SPELEEM also has the advantage of having a large dynamic range of view of up to ~100 micrometres thereby facilitating easy access to the structure of not only the nanometer but the micrometer scale as well. Finally, as the detection in SPELEEM is done at video-rates, monitoring of real-time dynamical processes is possible.
|Available for||Technique description|
|General Users||SPELEEM in the soft X-ray range|
Breaking down Keap1 ligands into fragments enables scientists to (re)construct new potent compounds
Inhibition of the interaction between Keap1 and Nrf2 proteins can help to prevent and reduce oxidative stress which, when left untreated, can cause neurological diseases, cancer, as well as cell and tissue damage. In a new project, scientists broke down existing compounds that have shown the ability to inhibit the Keap1–Nrf2 protein-protein interaction into fragments