BioMAX will be the first operational macromolecular crystallography beamline at MAX IV. It is a multipurpose high-throughput beamline for macromolecular crystallography. The beamline experiment set-up will be highly automated, in terms of both sample handling hardware and data analysis, including feedback on the data collection. The beamline aims to be robust and simple to operate with a beam benefiting from the properties of the MAX IV 3 GeV ring. It has been designed and will operate with the goal of delivering a high brilliance and stable X-ray beam with an energy range between 5–25 keV. Due to its extensive energy tunability, BioMAX is the ideal source for de novo phasing using the anomalous signal of heavy elements. It will be equipped with a high capacity sample changer and an Eiger 16M hybrid pixel detector, which designates the highest available performance hybrid pixel detector technology. Due to its small beam cross-section and optional parallel beam, BioMAX is the ideal experimental set-up for microcrystals and ultra large unit cells.
|Techniques||MX, MAD, SAD, SSAD, Atomic resolution data collection, Large sample ensemble screening, In situ crystal diffraction|
|Beam Size||20 x 5 μm2|
|Energy Range||5-25 keV|
|Samples||Single crystal (1 - 100 μm)|
First users at BioMAX
The first user experiment on FabG-NADP complex at BioMAX was carried out by Peter Vella, Robert Schnell, Gunter Schneider at the Division of Molecular Structural Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. The crystal structure of FabG from Acinetobacter baumannii was determined to 1.8 Å resolution from x-ray diffraction data collected at the